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pentobarbital will minimize the level or influence of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will decrease the level or outcome of alosetron by impacting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unfamiliar.Contraindicated (1)pentobarbital decreases levels of panobinostat by